Multifaceted activities of the plant SAGA complex

From yeast to human, the Spt-Ada-GCN5-acetyltransferase (SAGA) gigantic complex modifies chromatin during RNA polymerase II initiation and elongation steps facilitate transcription. Its enzymatic activity involves a histone acetyltransferase module (HATm) that acetylates multiple lysine residues on N-terminal tails of histones H2B H3 deubiquitination (DUBm) triggers co-transcriptional H2B. With few notable exceptions described in this review, most SAGA subunits identified metazoa are present plants. Studies from last 20 years have unveiled different involved gene expression regulation plant life cycle response various types stress or environmental cues. Their functional analysis Arabidopsis thaliana model species is increasingly shedding light their intrinsic properties how they can themselves be regulated adaptive responses. Recent biochemical studies also uncovered associations between machineries linked Pol Still, considerably less known about molecular links SAGA-like complexes dynamics transcription other species. We summarize emerging knowledge composition activity, with particular focus best-characterized its HAT (such as GCN5) DUB UBP22) modules, implication these ensembles development